The Gain of Rod Phototransduction Reconciliation of Biochemical and Electrophysiological Measurements

A comprehensive model of the phototransduction cascade in mouse rod cells.

Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian speci...

Current understanding of signal amplification in phototransduction

The studies of visual signal transduction, or phototransduction, have played a pivotal role in elucidating the most general principles of G protein signaling, particularly in regards to the concept of signal amplification, i.e., the process by which activation of a relatively small number of G protein coupled receptors is transformed into a robust downstream signaling event. In this essay, we s...

The Effects of the Tubulin-binding Drug, Colchicine, on the Electrophysiological Aspects of Phototransduction in Toad Rod Photoreceptors By

On-Line Nonlinear Dynamic Data Reconciliation Using Extended Kalman Filtering: Application to a Distillation Column and a CSTR

Extended Kalman Filtering (EKF) is a nonlinear dynamic data reconciliation (NDDR) method. One of its main advantages is its suitability for on-line applications. This paper presents an on-line NDDR method using EKF. It is implemented for two case studies, temperature measurements of a distillation column and concentration measurements of a CSTR. In each time step, random numbers with zero m...

Phototransduction in a transgenic mouse model of Nougaret night blindness.

The Nougaret form of dominant stationary night blindness is linked to a G38D mutation in the rod transducin-alpha subunit (Talpha). In this study, we have examined the mechanism of Nougaret night blindness using transgenic mice expressing TalphaG38D. The biochemical, electrophysiological, and vision-dependent behavioral analyses of the mouse model revealed a unique phenotype of reduced rod sens...